Skin disease after occupational dermal exposure to coal tar: a review of the scientific literature
@article{Moustafa2015SkinDA, title={Skin disease after occupational dermal exposure to coal tar: a review of the scientific literature}, author={Giannis A Moustafa and Eleni Xanthopoulou and Elena Riza and Athena Linos}, journal={International Journal of Dermatology}, year={2015}, volume={54} }
For about a century, coal tar has been used in industry and has been applied in the therapeutic management of several skin diseases. However, in the last decades the benefits of coal tar exploitation for humans could not outweigh its harmful effects on health. The aim of this study is to present the main adverse effects of coal tar on skin, with the emphasis on occupational exposure. The scientific literature indicates that dermal exposure to coal tar and coal tar pitches can be the cause of…
27 Citations
Review of the mechanism of action of coal tar in psoriasis
- ChemistryThe Journal of dermatological treatment
- 2018
Polycyclic aryl hydrocarbons, and specifically carbazole, are thought to be the mechanism by which crude coal tar has its effect in psoriasis, but further research is warranted to fully characterize the mechanism of action.
Occupational Acne
- Medicine
- 2019
The improvement in working conditions, taking preventive measures, and education of the workers could eliminate occupational acne as a problem.
Updated view of tars for psoriasis: what have we learned over the last decade?
- MedicineInternational journal of dermatology
- 2022
This review summarizes current knowledge about the chemical characterization, mechanism of action, toxicity, and clinical studies supporting the use of tars for psoriasis over the last decade, and trends within these above aspects are reviewed.
Pollution and Sun Exposure: A Deleterious Synergy. Mechanisms and Opportunities for Skin Protection.
- Environmental ScienceCurrent medicinal chemistry
- 2018
In people exposed to highly polluted environments, pollutants and sunlight may synergistically damage skin, requiring a specific protection.
Genotoxic changes in peripheral lymphocytes after therapeutic exposure to crude coal tar and ultraviolet radiation.
- Medicine, BiologyBiomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia
- 2016
The elevated levels of the DNA-DSBs and the chromosomal aberrations in the peripheral lymphocytes indicated a genotoxic hazard, however, the elevated level of the chromosome abnormalities was below the upper level ofThe reference range for healthy Czech adults.
Malignant Neoplasms of the Skin
- Medicine
- 2014
While the global burden of disease estimates suggest that the incidence of malignant neoplasms of the skin appears to be rising, this may be due to better diagnostic techniques, as well as greater exposure to sunlight and occupational carcinogens.
Comparison between two strategies of topical treatment in tar burn: a case report.
- MedicineJournal of burn care & research : official publication of the American Burn Association
- 2020
The impression was that the application of 1% silver sulfadiazine cream at the time of the admission, as well as in the following days, may be beneficial for the removal of the tar in close contact with the skin.
Importance of Dermal Absorption of Polycyclic Aromatic Hydrocarbons Derived from Barbecue Fumes.
- Environmental ScienceEnvironmental science & technology
- 2018
In the case of BBQ fumes, dermal absorption was a more important pathway for intake of low molecular-weight PAHs than inhalation.
Cancer risk in patients with psoriasis: should we be paying more attention?
- Medicine, BiologyExpert review of clinical immunology
- 2020
Patients with psoriasis have an increased risk of cancers overall and some site-specific cancers especially non-melanoma skin cancer, lymphoma, and lung cancer, and promotion of a healthy lifestyle is key in the prevention of certain cancer types.
References
SHOWING 1-10 OF 61 REFERENCES
No increased risk of cancer after coal tar treatment in patients with psoriasis or eczema.
- MedicineThe Journal of investigative dermatology
- 2010
Results indicate that coal tar can be maintained as a safe treatment in dermatological practice and has sufficient power to show that coalTar treatment is not associated with an increased risk of cancer.
Coal tar in dermatology
- MedicineThe Journal of dermatological treatment
- 2007
New, well‐designed, epidemiological studies are necessary to assess the risk of skin tumors and other malignancies after dermatological use of coal tar.
Occupationally related tumors in tar refinery workers.
- MedicineJournal of the American Academy of Dermatology
- 1998
[The toxicology and prevention of the risks of occupational exposure to aromatic polycyclic hydrocarbons. III. The effects: epidemiological evidence, early effects. Individual hypersusceptibility. Health surveillance].
- MedicineGiornale italiano di medicina del lavoro ed ergonomia
- 1997
On the basis of the current scientific data, it is not advisable the use of tumor markers or cytogenetic tests at the individual level as well as the screening of asymptomatic PAH exposed workers for early diagnosis of lung or bladder cancer.
Skin tumors among employees of a tar refinery: the current data and their implications
- MedicineInternational archives of occupational and environmental health
- 2007
Tar-induced skin lesions are still of importance nowadays, which is reflected in the incidence of new cases and in the relapses of skin tumors, and intensified measures are necessary, in the form of primary and secondary prevention.
Cancer risk from occupational and environmental exposure to polycyclic aromatic hydrocarbons
- MedicineCancer Causes & Control
- 2004
The lung seems to be the major target organ of PAH carcinogenicity and increased risk is present in most of the industries and occupations listed above, and the results of studies addressing environmental PAH exposure are consistent with these conclusions.
Bitumen fumes: review of work on the potential risk to workers and the present knowledge on its origin.
- Chemistry, BiologyThe Science of the total environment
- 2002
Final Safety Assessment of Coal Tar as Used in Cosmetics
- MedicineInternational journal of toxicology
- 2008
Coal Tar is a semisolid by-product obtained in the destructive distillation of bituminous coal, which functions in cosmetic products as a cosmetic biocide and denaturant—antidandruff agent is also…
Coal tar: past, present and future
- MedicineClinical and experimental dermatology
- 2002
The pharmacology, chemistry and use of crude coal is reviewed in order to reappraise its role as a therapeutic agent in dermatology.
The atrophogenic effect of crude coal tar on human epidermis
- BiologyThe British journal of dermatology
- 1981
Findings indicate that crude coal tar by itself can act as a cytostatic agent on normal human skin, when applied intensively.