Skin-derived stem cells transplanted into resorbable guides provide functional nerve regeneration after sciatic nerve resection.

@article{Marchesi2007SkinderivedSC,
  title={Skin-derived stem cells transplanted into resorbable guides provide functional nerve regeneration after sciatic nerve resection.},
  author={Chiara Marchesi and Mauro Pluderi and Federica Colleoni and Marzia Laura Chiara Belicchi and Mirella Meregalli and Andrea Farini and Daniele Parolini and Lorenza Draghi and Maria Elena Fruguglietti and Manuela Gavina and Laura Porretti and Antonino Cattaneo and Maurizio Battistelli and Alessandro Prelle and M. Moggio and Stefano Borsa and Lorena Bello and Diego Spagnoli and Sergio Gaini and M. Cristina Tanzi and Nereo Bresolin and Nadia Grimoldi and Yvan Torrente},
  journal={Glia},
  year={2007},
  volume={55 4},
  pages={425-38}
}
The regeneration in the peripheral nervous system is often incomplete and the treatment of severe lesions with nerve tissue loss is primarily aimed at recreating nerve continuity. Guide tubes of various types, filled with Schwann cells, stem cells, or nerve growth factors are attractive as an alternative therapy to nerve grafts. In this study, we evaluated whether skin-derived stem cells (SDSCs) can improve peripheral nerve regeneration after transplantation into nerve guides. We compared… CONTINUE READING

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