Skin deposition and permeation of finasteride in vitro: effects of propylene glycol, ethanol and sodium lauryl sulfate

@article{Limpongsa2015SkinDA,
  title={Skin deposition and permeation of finasteride in vitro: effects of propylene glycol, ethanol and sodium lauryl sulfate},
  author={Ekapol Limpongsa and Napaphak Jaipakdee and T. Pongjanyakul},
  journal={Pharmaceutical Development and Technology},
  year={2015},
  volume={20},
  pages={984 - 991}
}
  • Ekapol Limpongsa, Napaphak Jaipakdee, T. Pongjanyakul
  • Published 2015
  • Chemistry, Medicine
  • Pharmaceutical Development and Technology
  • Abstract The objective of this study was to investigate the effects of propylene glycol (PG), ethanol (EtOH) and sodium lauryl sulfate (SLS) on the in vitro deposition and permeation of finasteride (FNS). A side-by-side diffusion cell mounted with a pig ear skin and a saturated solution of FNS in PG (10, 20% v/v), EtOH (10, 20% v/v) or SLS (0.5, 1% w/v) vehicles were used. Incorporation of PG, EtOH or SLS caused a significant increase in FNS solubility both in the solution and on the skin with… CONTINUE READING
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