Skin delivery of short hairpin RNA of indoleamine 2,3 dioxygenase induces antitumor immunity against orthotopic and metastatic liver cancer.

@article{Huang2011SkinDO,
  title={Skin delivery of short hairpin RNA of indoleamine 2,3 dioxygenase induces antitumor immunity against orthotopic and metastatic liver cancer.},
  author={Tzu-Ting Huang and Meng-Chi Yen and Chi-Chien Lin and Tzu-Yang Weng and Yi-Ling Chen and Chiu-Mei Lin and M D Lai},
  journal={Cancer science},
  year={2011},
  volume={102 12},
  pages={2214-20}
}
Liver cancer is one of the most malignant cancers in the world and has a high rate of metastasis. Therefore, development of a novel therapy for liver cancer is a critical issue. Indoleamine 2,3-dioxygenase (IDO) is known as a negative immune regulator in dendritic cells. Our previous study demonstrated that skin delivery of IDO short hairpin RNA (shRNA) induced antitumor immunity in subcutaneous bladder and colon tumor models. Because the immunological environment is quite different between… CONTINUE READING
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