Skin cytogenetic assay for the detection of clastogens-carcinogens topically administered to mice.

@article{Barale1992SkinCA,
  title={Skin cytogenetic assay for the detection of clastogens-carcinogens topically administered to mice.},
  author={Roberto Barale and Chiara Scapoli and A. Falezza and Luca Ventura and F Bernacchi and Nicola Loprieno and Italo Barrai},
  journal={Mutation research},
  year={1992},
  volume={271 3},
  pages={223-30}
}
A method for assessing the effect of clastogens on mouse skin epidermal cells was devised and applied. Toxic and mutagenic responses in epidermal cells were tested using two known mutagens and carcinogens, urethane (URE) and 7,12-dimethylbenz[a]anthracene (DMBA). Cell generation time, sister-chromatid exchanges (SCE) and chromosomal aberrations (CA) after topical and intraperitoneal (i.p.) treatment were measured in epidermal and bone marrow cells. After topical administration both tissues… CONTINUE READING