The liver is the second largest organ in the human body. An association between the skin and the liver has been recognized for centuries. Indeed, there is not always a correlation between the severity of the liver disease and the skin changes and they often are not specific. Several types of interaction between the skin and the liver are encountered: 1. Liver disease may cause skin changes. 2. The skin and the liver may be involved by the same pathologic process. 3. Skin disease may cause-liver abnormalities. 4. The liver may be damaged by drugs used to treat skin disease. In the following, the first two conditions are discussed.