Skin cancer in organ transplant recipients: effects of immunosuppressive medications on DNA repair

@article{Kuschal2012SkinCI,
  title={Skin cancer in organ transplant recipients: effects of immunosuppressive medications on DNA repair},
  author={Christiane Kuschal and Kai M. Thoms and Steffen Schubert and Annika Sch{\"a}fer and Lars Boeckmann and Michael P. Sch{\"o}n and Steffen Emmert},
  journal={Experimental Dermatology},
  year={2012},
  volume={21}
}
Abstract:  UV‐induced skin cancers comprise a major problem in organ transplant recipients (OTRs). Cyclosporin A, a calcineurin inhibitor, is used as a standard immunosuppressant and clearly increases the skin cancer risk. Azathioprine does not appear to result in such an increase in skin cancer risk, and mTOR inhibitors are associated with an even lesser skin cancer risk. The underlying molecular mechanisms of these clinically important differences among immunosuppressants are still unclear… 

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Update: Solar UV Radiation, Vitamin D, and Skin Cancer Surveillance in Organ Transplant Recipients (OTRs).

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  • Medicine, Biology
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  • 2019
These epidemiologic observations suggest that there are 2 distinct immune selection processes in humans: immunosurveillance directed against premalignant cells before cancer diagnosis (most relevant for preventing virus‐related cancers), and “immunocontainment” directed against established cancers.
...

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