Skin cancer: In melanoma ulceration, size matters


Numerous studies have assessed the prognostic value of the size of ulceration in clinically localized cutaneous melanoma. In fact, the presence of ulceration was already established as an adverse prognostic factor back in the 1950s. Now, the team led by John Thompson and Richard Scolyer has not only confirmed the importance of the extent of ulceration in predicting melanoma prognosis, but has also described how the size of the ulceration is actually a better prognosis factor than the mere presence or absence of ulceration. The study included 521 patients with ulcerated melanoma and 4,140 patients with non-ulcerated melanoma. The patients were then distributed into different categories: patients with absence or presence of ulceration; minimally/ moderately ulcerated disease (in whom the percentage of ulceration was ≤70% or ≤5 mm, n = 163 and 388 respectively); and extensive ulcerated tumours (in whom the extent of the ulceration was >70% or >5 mm, n = 54 and 133 respectively). The SKIN CANCER

DOI: 10.1038/nrclinonc.2012.90

Cite this paper

@article{Villanueva2012SkinCI, title={Skin cancer: In melanoma ulceration, size matters}, author={M. Teresa Villanueva}, journal={Nature Reviews Clinical Oncology}, year={2012}, volume={9}, pages={370-370} }