Skin biopsy immunostaining with a Notch3 monoclonal antibody for CADASIL diagnosis.

@article{Joutel2001SkinBI,
  title={Skin biopsy immunostaining with a Notch3 monoclonal antibody for CADASIL diagnosis.},
  author={Anne Joutel and Pascal Favrole and Pierre Labauge and Hugues Chabriat and Christelle Lescoat and Fr{\'e}d{\'e}ric Andreux and Val{\'e}rie Domenga and Michaelle C{\'e}cillon and Katayoun Vahedi and Anne Ducros and Florence Cav{\'e}-Riant and Marie Germaine Bousser and Elizabeth Tournier-Lasserve},
  journal={Lancet},
  year={2001},
  volume={358 9298},
  pages={2049-51}
}
CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy) is a small-artery disease of the brain caused by NOTCH3 mutations that lead to an abnormal accumulation of NOTCH3 within the vasculature. We aimed to establish whether immunostaining skin biopsy samples with a monoclonal antibody specific for NOTCH3 could form the basis of a reliable and easy diagnostic test. We compared the sensitivity and specificity of this method in two groups of patients… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 85 extracted citations

Similar Papers

Loading similar papers…