Skin Penetration and Sun Protection Factor of Five UV Filters: Effect of the Vehicle

  title={Skin Penetration and Sun Protection Factor of Five UV Filters: Effect of the Vehicle},
  author={Eric Chatelain and Bernard Gabard and Christian Surber},
  journal={Skin Pharmacology and Physiology},
  pages={28 - 35}
To gain information about efficacy and safety of sunscreens, we compared the skin penetration of ultraviolet (UV) filters from two vehicles, i.e. an oil-in-water (O/W) emulsion gel and petrolatum jelly both in vitro and in vivo, as well as the corresponding pharmacological effect, i.e. the sun protection factor (SPF) in vivo. The UV filters studied were benzophenone-3 (BPH), ethylhexyl methoxycinnamate (EHM), butyl methoxydibenzoyl methane, ethylhexyl salicylate and homosalate. The human skin… 

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