Skin-Derived SPINK9 Kills Escherichia coli.

@article{Wu2019SkinDerivedSK,
  title={Skin-Derived SPINK9 Kills Escherichia coli.},
  author={Zhihong Wu and Yuanyuan Wu and J. Fischer and J. Bartels and J. Schr{\"o}der and U. Meyer-Hoffert},
  journal={The Journal of investigative dermatology},
  year={2019},
  volume={139 5},
  pages={
          1135-1142
        }
}
Antimicrobial peptides play a critical role in the barrier function of human skin. They offer a fast response to invading microorganisms and protect from external microbial infection. Here we show the isolation of the kallikrein-related peptidase inhibitor SPINK9 as a major antibacterial factor from healthy stratum corneum. In total, six N-terminal SPINK9 variants were identified in the stratum corneum. Whereas all variants exhibited similar inhibition activities against kallikrein-related… Expand

References

SHOWING 1-10 OF 41 REFERENCES
Antileukoprotease in human skin: an antibiotic peptide constitutively produced by keratinocytes.
Antimicrobial peptides in human skin disease.
Isolation of SPINK6 in Human Skin
The Expression of the Gene Coding for the Antibacterial Peptide LL-37 Is Induced in Human Keratinocytes during Inflammatory Disorders*
  • Margareta Frohm, Birgitta Agerberth, +4 authors G. H. Gudmundsson
  • Medicine, Biology
  • The Journal of Biological Chemistry
  • 1997
RNase 7, a Novel Innate Immune Defense Antimicrobial Protein of Healthy Human Skin*
SPINK9 stimulates metalloprotease/EGFR-dependent keratinocyte migration via purinergic receptor activation.
...
1
2
3
4
5
...