Skin Breakdown and Blisters from Senna-Containing Laxatives in Young Children

@article{Spiller2003SkinBA,
  title={Skin Breakdown and Blisters from Senna-Containing Laxatives in Young Children},
  author={Henry A. Spiller and Mark L. Winter and J A Weber and Edward P. Krenzelok and Deborah L Anderson and Mark Ryan},
  journal={Annals of Pharmacotherapy},
  year={2003},
  volume={37},
  pages={636 - 639}
}
BACKGROUND: At the direction of the Food and Drug Administration, phenolphthalein was removed from all over-the-counter laxatives in 1999. Phenolphthalein was then replaced in most laxative products with the natural product senna from Cassia acutifolia Delile, which contains various anthraquinones. No data are available on the safety of senna use in children <6 years of age. OBJECTIVE: To describe the clinical outcomes of exposure to unintentional ingestion of senna-containing laxatives in… 

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References

SHOWING 1-7 OF 7 REFERENCES

Laxative-induced dermatitis of the buttocks incorrectly suspected to Be abusive burns.

TLDR
In each case, a more detailed history revealed that the child's burn was not attributable to immersion in hot water, but rather resulted from the ingestion of Ex-Lax (Novartis, Summit, NJ), and there are no previous reports of this type of injury in children.

Diarrhea, Red Diapers, and Child Abuse

TLDR
Three children were chronically given phenolphthalein in the form of laxatives by emotionally disturbed mothers and one child died, representing a heretofore unrecognized variant of child abuse or battering.

Laxatives and the special role of senna.

TLDR
Standardised senna is the most physiological of all the non-fibre laxatives and is safe when used in appropriate dosage avoiding loose stools.

Acute phenolphthalein ingestion in children. A retrospective review.

A controlled trial of senna preparations and other laxatives used for bowel cleansing prior to radiological examination.

TLDR
Film quality of PP, X-P and HP methods shows only small differences, and PP gives fewer side effects (cramps) than HP andX-P, and low residue dietary measures are essential for a good result.