Skin Breakdown and Blisters from Senna-Containing Laxatives in Young Children

  title={Skin Breakdown and Blisters from Senna-Containing Laxatives in Young Children},
  author={Henry A. Spiller and Mark L. Winter and J A Weber and Edward P. Krenzelok and Deborah L Anderson and Mark Ryan},
  journal={Annals of Pharmacotherapy},
  pages={636 - 639}
BACKGROUND: At the direction of the Food and Drug Administration, phenolphthalein was removed from all over-the-counter laxatives in 1999. Phenolphthalein was then replaced in most laxative products with the natural product senna from Cassia acutifolia Delile, which contains various anthraquinones. No data are available on the safety of senna use in children <6 years of age. OBJECTIVE: To describe the clinical outcomes of exposure to unintentional ingestion of senna-containing laxatives in… 

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