Skin Aging and Menopause

  title={Skin Aging and Menopause},
  author={Nicholas Raine-Fenning and Mark P. Brincat and Yves Muscat-Baron},
  journal={American Journal of Clinical Dermatology},
The skin is one of the largest organs of the body, which is significantly affected by the aging process and menopause. The significant changes sustained by the skin during the menopause are due to the effect sustained on the skin’s individual components.The estrogen receptor has been detected on the cellular components of the skin. Accordingly, dermal cellular metabolism is influenced by the hypoestrogenoemic state of menopause leading to changes in the collagen content, alterations in the… 

The role of cytokines in skin aging

Cutaneous aging is one of the major noticeable menopausal complications that most women want to fight in their quest for an eternally youthful skin appearance and further research is required especially to establish the role of cytokines in the treatment of cutaneous aging.

Menopause and skin aging

Although skin aging is certainly no indication for the hormone replacement therapy the beneficial effect of estrogen supplementation on the skin appearance is a positive side aspect of such treatment.

The Effect of Cytokines on Skin During Menopause

The decrease in estrogen level that occurs in menopause brings an imbalanced level of cytokines that causes several menopausal complications including cutaneous aging which, although not life-threatening, affects the well-being and quality of life of elderly women.

Skin aging and sex hormones in women – clinical perspectives for intervention by hormone replacement therapy

It is obvious that hormone replacement should not be administered as an independent treatment for skin aging, and phytohormones may be administered, with the structural similarity to 17β‐estradiol explaining their estrogen‐like effects.

Biology of estrogens in skin: implications for skin aging

Although systemic hormone replacement therapy (HRT) has been used for many years, recent trials have reported a significant increased risk of breast cancer and other pathologies with this treatment, and this has led to reconsider the risks and benefits of HRT.

Estrogen and Skin

The promises and challenges of utilizing topical estrogens, SERMs, and phytoestrogens in postmenopausal skin management are discussed and safe and effective alternatives with more focused effects on the skin are explored.

Menapoz ve Deri

Skin aging is a process starting with thinning of the skin, followed by the skin becoming damaged more easily and ending with wrinkling and an increased number of deeper wrinkles.



Estrogen and Skin

The role of estrogen in scarring is unclear but recent studies indicate that the lack of estrogen or the addition of tamoxifen may improve the quality of scarring.

Long‐term effects of the menopause and sex hormones on skin thickness

The data suggest that skin collagen is influenced by the sex hormone status arid declines after the menopause contributing to the increase in urinary hydroxyproline excretion that has been reported to occur this time.

A Study of the Decrease of Skin Collagen Content, Skin Thickness, and Bone Mass in the Postmenopausal Woman

The skin collagen content, skin thickness, metacarpal index, and forearm bone mineral content in postmenopausal women showed a similar decline of between 1–2% per year after the menopause, suggesting that a similar pathology causes the decrease in bone mass and skin thickness.

Hormone Receptors in Pubic Skin of Premenopausal and Postmenopausal Females

Pubic skin of a total of 106 females was obtained during gynecologic operations for determination of estrogen receptors, androgen receptors (AR) and gestagen receptors (PgR) by saturation analysis and no significant differences between ER of premenopausal and postmenopausal skin became evident.

Estrogen accelerates cutaneous wound healing associated with an increase in TGF-β1 levels

It is reported that aging in healthy females was associated with a reduced rate of cutaneous wound healing, but an improved quality of scarring both microscopically and macroscopically, and with reduced levels of transforming growth factor-β1 immuno staining and steady-state mRNA in the wound.

Sex hormones and skin collagen content in postmenopausal women.

The finding is that oestrogen or testosterone, or both, prevents the decrease in skin collagen content that occurs with aging and protects skin in the same way as it protects bone in postmenopausal women.

Decline in skin collagen content and metacarpal index after the menopause and its prevention with sex hormone replacement

There was a statistically significant decrease both in the thigh skin collagen content and in the metacarpal index with the years since the menopause, and this decrease was preventable in women who were on sex hormone replacement therapy.