Skin‐sensitizing and irritant properties of propylene glycol

@article{Lessmann2005SkinsensitizingAI,
  title={Skin‐sensitizing and irritant properties of propylene glycol},
  author={Holger Lessmann and Axel Schnuch and Johannes Geier and Wolfgang Uter},
  journal={Contact Dermatitis},
  year={2005},
  volume={53}
}
In the several publications reviewed in this article, propylene glycol (PG; 1,2‐propylene glycol) is described as a very weak contact sensitizer, if at all. However, particular exposures to PG‐containing products might be associated with an elevated risk of sensitization. To identify such exposures, we analysed patch test data of 45 138 patients who have been tested with 20% PG in water between 1992 and 2002. Out of these, 1044 patients (2.3%) tested positively, 1083 showed a doubtful… Expand
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References

SHOWING 1-10 OF 122 REFERENCES
Propylene glycol dermatitis: re‐evaluation of an old problem
TLDR
Future studies on propylene glycol dermatitis should include repeated patch tests with serial dose dilutions, repeated open application tests/pro vocative use tests, oral challenge tests, and biopsies for a more complete evaluation of mechanisms and clinical significance. Expand
Skin reactions to hexylene glycol
TLDR
The present results suggest that HG is less irritating than PG under occlusion, but that delayed contact allergic reactions may occur. Expand
Hautreizungen durch Propylenglykol
TLDR
Skin reactions due to propylene glycol are rare and should not bring the preparation into unnecessary discredit, but the possibility of propylene Glycol allergy should be recognized by dermatologists as propyleneglycol is used in local steroids and other topical preparations. Expand
Contact allergy from propylene glycol
Propylene glycol (PG) 20% in water was tested in a group of 400 subjects with eczematous contact dermatitis. In six inpatients (1.5%) reactions were recorded as considered positive according to the… Expand
Irritant thresholds in subjects withcolophony allergy
TLDR
The results are consistent with the hypothesis that individuals with enhanced susceptibility to skin irritation are also more liable to develop allergic skin reactivity. Expand
Skin reactions to propylene glycol
TLDR
PG and topical preparations containing it in high concentrations should not be used with occlusion, and that allergic reactions must be watched. Expand
Experimentally‐induced irritant contact dermatitis
TLDR
Responder rates lower than 75% had to be accepted for benzalkonium chloride and sodium hydroxide in order to prevent overly severe reactions, whilst propylene glycol proved to have only marginal irritant properties. Expand
propylene Glycol: Search for a Proper and Nonirritant Patch Test Preparation
Several contact allergens are also irritants. The ideal test preparation should not miss cases of contact allergy and should be nonirritant. The purpose of this study was to compare the… Expand
Histological aspects of skin reactions to propylene glycol
TLDR
Patch tests were performed with pure PG in a group of 98 out‐patients at a skin clinic with no indication of a possible allergic contact dermatitis to PG, and the observed reactions were considered to be of a primary irritant nature. Expand
Patch testing with the irritant sodium lauryl sulfate (SLS) is useful in interpreting weak reactions to contact allergens as allergic or irritant
TLDR
For the first time, a significant association between reactivity to the irritant SLS and erythematous reactions to certain allergens is revealed, and some reactions can now be classified as irritant more confidently, particularly if there is no history of exposure to the allergen. Expand
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