Ski and SnoN: negative regulators of TGF-beta signaling.

  title={Ski and SnoN: negative regulators of TGF-beta signaling.},
  author={K. C. K. Luo},
  journal={Current opinion in genetics & development},
  volume={14 1},
  • K. C. K. Luo
  • Published 2004 in Current opinion in genetics & development
Ski and SnoN are unique proto-oncoproteins in that they can induce both oncogenic transformation and terminal muscle differentiation when expressed at high levels. Recent studies using in vitro and in vivo approaches have begun to unravel the complex roles of Ski and SnoN in tumorigenesis and embryonic development. The identification of Ski and SnoN as important negative regulators of signal transduction by the transforming growth factor-beta superfamily of cytokines provides a valuable… CONTINUE READING
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