SkfB Abstracts a Hydrogen Atom from Cα on SkfA To Initiate Thioether Cross-Link Formation.

Abstract

Sulfur to α-carbon thioether-containing peptides (sactipeptides) are ribosomally synthesized post-translationally modified peptides with bacteriocidal activities. The thioether cross-link, which is required for biological activity, is installed by a member of the radical S-adenosyl-l-methionine (SAM) superfamily in the peptide substrate. Herein, we show… (More)
DOI: 10.1021/acs.biochem.6b00598

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@article{Bruender2016SkfBAA, title={SkfB Abstracts a Hydrogen Atom from Cα on SkfA To Initiate Thioether Cross-Link Formation.}, author={Nathan A Bruender and Vahe Bandarian}, journal={Biochemistry}, year={2016}, volume={55 30}, pages={4131-4} }