Skewed expression of natural-killer (NK)-associated antigens on lymphoproliferations of large granular lymphocytes (LGL).

@article{Fischer2006SkewedEO,
  title={Skewed expression of natural-killer (NK)-associated antigens on lymphoproliferations of large granular lymphocytes (LGL).},
  author={Lars Fischer and Michael John Hummel and Thomas Burmeister and Stefan Schwartz and Eddy Van Thiel},
  journal={Hematological oncology},
  year={2006},
  volume={24 2},
  pages={
          78-85
        }
}
Killer-immunoglobulin-like receptors (KIR) or C-type lectin-like receptors are heterogeneously expressed on NK cells and small subsets of T cells and might provide a new diagnostic tool for LGL lymphoproliferations (LGLL). We investigated the diagnostic impact of these cell surface molecules in T- and NK-type LGLL. Using three-color flow cytometry we examined the expression patterns of KIR (CD158a/b/e/i), CD85j, lectin-like receptors (CD94, CD161, NKG2A/D) and natural cytotoxicity receptors… CONTINUE READING
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