Skewed X-chromosome inactivation is a common feature of X-linked mental retardation disorders.

@article{Plenge2002SkewedXI,
  title={Skewed X-chromosome inactivation is a common feature of X-linked mental retardation disorders.},
  author={Robert M. Plenge and Roger Stevenson and Herbert A. Lubs and Charles E. Schwartz and Huntington F. Willard},
  journal={American journal of human genetics},
  year={2002},
  volume={71 1},
  pages={168-73}
}
Some deleterious X-linked mutations may result in a growth disadvantage for those cells in which the mutation, when on the active X chromosome, affects cell proliferation or viability. To explore the relationship between skewed X-chromosome inactivation and X-linked mental retardation (XLMR) disorders, we used the androgen receptor X-inactivation assay to determine X-inactivation patterns in 155 female subjects from 24 families segregating 20 distinct XLMR disorders. Among XLMR carriers… CONTINUE READING
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