Skewed X chromosome inactivation and female preponderance in autoimmune thyroid disease: an association study and meta-analysis.

@article{Simmonds2014SkewedXC,
  title={Skewed X chromosome inactivation and female preponderance in autoimmune thyroid disease: an association study and meta-analysis.},
  author={Matthew James Simmonds and Fotini K. Kavvoura and Oliver J. Brand and Paul R. T. Newby and Laura Estella Jackson and Chantal E Hargreaves and Jayne A. Franklyn and Stephen C. L. Gough},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2014},
  volume={99 1},
  pages={
          E127-31
        }
}
CONTEXT A number of small data sets have suggested a potential role for skewed X chromosome activation (XCI), away from the expected 50:50 parent of origin ratio, as an explanation for the strong female preponderance seen in the common autoimmune thyroid diseases (AITD), Graves' disease (GD), and Hashimoto's thyroiditis (HT). OBJECTIVE The objective of the study was to confirm a role for XCI skewing as a potential explanation for the strong female preponderance seen in AITD. DESIGN The… CONTINUE READING
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