Sketches of Otohistory Part 11: Ototoxicity: Drug-Induced Hearing Loss

@article{Schacht2006SketchesOO,
  title={Sketches of Otohistory Part 11: Ototoxicity: Drug-Induced Hearing Loss},
  author={Jochen Schacht and Joseph E. Hawkins},
  journal={Audiology and Neurotology},
  year={2006},
  volume={11},
  pages={1 - 6}
}
trolled, any untoward action of the drug simply was accepted as inevitable consequence. Secondly, we must consider the status of deafness itself in historic times. Concern for the handicapped was not part of the social fabric of early societies, with the Spartans probably being the most notorious example; in Spartan culture, children born with or suspected of birth defects were tossed off the cliffs. In ancient Israel, those born deaf could not own property or conduct business transactions… 

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References

SHOWING 1-10 OF 20 REFERENCES
Salicylate attenuates gentamicin-induced ototoxicity.
  • S. Sha, J. Schacht
  • Biology, Medicine
    Laboratory investigation; a journal of technical methods and pathology
  • 1999
TLDR
It is demonstrated that 2-hydroxybenzoate (salicylate), which can act as an iron chelator and antioxidant, effectively protects against gentamicin-induced hearing loss in guinea pigs and holds promise for clinical application.
Ototoxicity of cis-dichlorodiammine platinum (II) in the guinea pig.
The discovery of aspirin: a reappraisal
  • W. Sneader
  • Chemistry
    BMJ : British Medical Journal
  • 2000
TLDR
Analysis of relevant archival and published material now supports Eichengrun's claim that the work had been done under his direction and throws doubt on the reliability of the source crediting Hoffmann.
Some historical aspects of ototoxicity.
TLDR
The present brief account traces some early reports of ototoxicity from the time of Richard Morton (1692) onwards.
Preliminary clinical experience with cis‐diamminedichloroplatinum (II) (NSC 119875, CACP)
TLDR
Toxicity to the initial course of CACP, up to 90 mg/m2 BSA, was minimal and transient in most patients, but at higher dosage levels or following repeat courses, the drug‐related toxicity was more severe.
Ototoxicity: bioprotective mechanisms
  • L. Rybak, T. Kelly
  • Biology, Medicine
    Current opinion in otolaryngology & head and neck surgery
  • 2003
TLDR
This review discusses current research dealing with novel approaches to the prevention of ototoxicity caused by cisplatin and aminoglycoside antibiotics, and provides the potential for exciting clinical trials to determine whether the animal experiments can be translated into rational therapeutic approaches.
On the antibacterial action of cultures of a penicillium, with special reference to their use in the isolation of B. influenzæ
TLDR
It is suggested that it may be an efficient antiseptic for application to, or injection into, areas infected with penicillin-sensitive microbes, and its value as an aid to the isolation of B. influenzae has been demonstrated.
Ototoxicity of ethacrynic acid and aminoglycoside antibiotics in uremia.
TLDR
The ototoxic effects of aminoglycosides such as streptomycin, kanamycin and neomycin are well established and since renal failure increases the hazard of ototoxicity from these drugs, it can be expect that these drugs will cause renal failure.
Streptomycin, a substance exhibiting antibiotic activity against gram-positive and gram-negative bacteria. 1944.
TLDR
The figure captions accompanying this article are incorrect and the two men were co-discoverers of streptomycin.
Streptomycin, a Substance Exhibiting Antibiotic Activity Against Gram-Positive and Gram-Negative Bacteria.∗†
Summary A new antibacterial substance, designated as streptomycin, was isolated from two strains of an actinomyces related to an organism described as Actinomyces griseus. This substance resembles
...
...