Skeletal receptors for steroid-family regulating glycoprotein hormones: A multilevel, integrated physiological control system.

@article{Blair2011SkeletalRF,
  title={Skeletal receptors for steroid-family regulating glycoprotein hormones: A multilevel, integrated physiological control system.},
  author={Harry C. Blair and Lisa J. Robinson and Li Sun and Carlos M. Isales and Terry F Davies and M Shoaib Zaidi},
  journal={Annals of the New York Academy of Sciences},
  year={2011},
  volume={1240},
  pages={
          26-31
        }
}
Pituitary glycoprotein hormone receptors, including ACTH-R, TSH-R, and FSH-R, occur in bone. Their skeletal expression reflects that central endocrine control is evolutionarily recent. ACTH receptors, in osteoblasts or the adrenal cortex, drive VEGF synthesis. VEGF is essential to maintain vasculature. In bone, ACTH suppression by glucocorticoids can cause osteonecrosis. TSH receptors occur on osteoblasts and osteoclasts, in both cases reducing activity. Thus, TSH directly reduces skeletal… CONTINUE READING
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