Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3

@article{Colvin1996SkeletalOA,
  title={Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3},
  author={Jennifer Sue Colvin and Barbara A. Bohne and Gary W. Harding and Donald G. McEwen and David M Ornitz},
  journal={Nature Genetics},
  year={1996},
  volume={12},
  pages={390-397}
}
Fibroblast growth factor receptor 3 (Fgfr3) is a tyrosine kinase receptor expressed in developing bone, cochlea, brain and spinal cord. Achondroplasia, the most common genetic form of dwarfism, is caused by mutations in FGFR3. Here we show that mice homozygous for a targeted disruption of Fgfr3 exhibit skeletal and inner ear defects. Skeletal defects include kyphosis, scoliosis, crooked tails and curvature and overgrowth of long bones and vertebrae. Contrasts between the skeletal phenotype and… CONTINUE READING
Highly Influential
This paper has highly influenced 27 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS