Skeletal overexpression of connective tissue growth factor impairs bone formation and causes osteopenia.

@article{SmerdelRamoya2008SkeletalOO,
  title={Skeletal overexpression of connective tissue growth factor impairs bone formation and causes osteopenia.},
  author={Anna Smerdel-Ramoya and Stefano Zanotti and Lisa E Stadmeyer and Deena Durant and Ernesto Canalis},
  journal={Endocrinology},
  year={2008},
  volume={149 9},
  pages={
          4374-81
        }
}
Connective tissue growth factor (CTGF), a member of the CCN family of proteins, is expressed in skeletal cells, and the ctgf null mutation leads to neonatal lethality due to defects in skeletal development. To define the function of CTGF in the postnatal skeleton, we created transgenic mice overexpressing CTGF under the control of the human osteocalcin promoter. CTGF transgenic female and male mice exhibited a significant decrease in bone mineral density, compared with wild-type littermate… CONTINUE READING
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