Skeletal myoblasts for heart regeneration and repair: state of the art and perspectives on the mechanisms for functional cardiac benefits.

@article{Formigli2010SkeletalMF,
  title={Skeletal myoblasts for heart regeneration and repair: state of the art and perspectives on the mechanisms for functional cardiac benefits.},
  author={Lucia Formigli and Sandra Zecchi-Orlandini and Elisabetta Meacci and Daniele Bani},
  journal={Current pharmaceutical design},
  year={2010},
  volume={16 8},
  pages={
          915-28
        }
}
Until recently, skeletal myoblasts (SkMBs) have been the most widely used cells in basic research and clinical trials of cell based therapy for cardiac repair and regeneration. Although SkMB engraftment into the post-infarcted heart has been consistently found to improve cardiac contractile function, the underlying therapeutic mechanisms remain still a matter of controversy and debate. This is basically because SkMBs do not attain a cardiac-like phenotype once homed into the diseased heart nor… CONTINUE READING

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