Skeletal myoblast transplantation for attenuation of hyperglycaemia, hyperinsulinaemia and glucose intolerance in a mouse model of type 2 diabetes mellitus

@article{Ye2009SkeletalMT,
  title={Skeletal myoblast transplantation for attenuation of hyperglycaemia, hyperinsulinaemia and glucose intolerance in a mouse model of type 2 diabetes mellitus},
  author={Lei Ye and Kok Onn Lee and Liping Su and Wee Chi Toh and Husnain Kh. Haider and Peter K. Law and Weizhen Zhang and Suk Ping Chan and Eugene K. W. Sim},
  journal={Diabetologia},
  year={2009},
  volume={52},
  pages={1925-1934}
}
We aimed to demonstrate the feasibility and efficacy of intra-muscular transplantation of human skeletal myoblasts (hSkMs) for attenuation of hyperglycaemia and improvement of insulin sensitivity using a mouse model of type 2 diabetes mellitus. KK Cg-Ay/J mice, aged 12 to 14 weeks, underwent an initial intraperitoneal glucose tolerance test (GTT) and were divided into the following groups: KK control group, basal medium (M199) only; KK myoblast group, with hSkM transplantation; KK fibroblast… CONTINUE READING
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