Skeletal muscle triglycerides lowering is associated with net improvement of insulin sensitivity, TNF-α reduction and GLUT4 expression enhancement

@article{Mingrone2002SkeletalMT,
  title={Skeletal muscle triglycerides lowering is associated with net improvement of insulin sensitivity, TNF-α reduction and GLUT4 expression enhancement},
  author={G. Mingrone and Giuseppina La Rosa and P Di Rocco and Melania Manco and Esmeralda Capristo and Marco Castagneto and Roberto Vettor and Giovanni Battista Gasbarrini and A V Greco},
  journal={International Journal of Obesity},
  year={2002},
  volume={26},
  pages={1165-1172}
}
AIMS/HYPOTHESIS: The aim of the present study was to investigate the relationship between intramyocytic triglycerides levels, muscle TNF-α and GLUT4 expression and insulin resistance.METHODS: Insulin sensitivity was studied in 14 severely obese women (BMI>40 kg/m2), before and 6 months after low-dietary intake or bariatric malabsorptive surgery (bilio-pancreatic diversion, BPD), by the euglycaemic hyperinsulinaemic clamp technique, while the amount of intramyocytic triglycerides was chemically… CONTINUE READING

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