Skeletal muscle-specific immunotoxin for the treatment of focal muscle spasm.

@article{Hott1998SkeletalMI,
  title={Skeletal muscle-specific immunotoxin for the treatment of focal muscle spasm.},
  author={J S Hott and Marinos C. Dalakas and C. S. Sung and M. Hallett and Richard J Youle},
  journal={Neurology},
  year={1998},
  volume={50 2},
  pages={
          485-91
        }
}
Intramuscular injection of botulinum toxin type A (BTX) is used to treat many disorders characterized by muscular spasms. The utility of BTX, however, is limited by its short duration of action, the development of resistance after repeated injections, and cross-reactivity with autonomic neurons. To overcome these limitations, we engineered an immunotoxin (ITX) to damage skeletal muscle fibers selectively by chemically linking a monoclonal antibody against the nicotinic acetylcholine receptor to… CONTINUE READING

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