Skeletal muscle necrosis following membrane-active drugs plus serotonin

@article{Meltzer1976SkeletalMN,
  title={Skeletal muscle necrosis following membrane-active drugs plus serotonin},
  author={Herbert Y. Meltzer},
  journal={Journal of the Neurological Sciences},
  year={1976},
  volume={28},
  pages={41-56}
}
  • H. Meltzer
  • Published 1 May 1976
  • Biology
  • Journal of the Neurological Sciences
Serotonin accumulation by skeletal muscle
Serotonin Metabolism in the Normal and Failing Hamster Heart
TLDR
Both the stores and synthesis of serotonin are reduced in the failing myopathic hamster heart, indicating significant stores of serotonin synthesized within the heart.
Pre-clinical study of 21 approved drugs in the mdx mouse
Nerve, muscle, and serotonin.
  • M. Takamori
  • Biology, Medicine
    Journal of neurology, neurosurgery, and psychiatry
  • 1977
TLDR
Effects of serotonin one neuromuscular transmission and muscle contraction were studied in the tibialis anterior of rabbits; pharmacological mechanisms are discussed in comparison with those of adrenaline and isoprenaline.
5-Hydroxytryptamine potentiates post-tetanic twitch responses in the rat phrenic nerve diaphragm preparation.
TLDR
It is demonstrated that 5-hydroxytryptamine does have significant effects upon the neuromuscular junction under conditions of physiological compromise (following tetanus) and these observations are the first step, therefore, in a series of studies aimed at identifying the resident 5-HydroxyTryptamine receptors within the neuron junction which will subsequently enable us to predict therapeutic effect or toxicity.
Serotonin uptake in blood platelets of duchenne muscular dystrophy patients
TLDR
There was a significant negative correlation between serum creatine kinase activity and Km of 5‐HT uptake in blood platelets of patients with Duchenne‐type muscular dystrophy, but no correlation was found between Km or Vmax and ambulatory status of DMD.
5-Hydroxytryptamine causes depression of twitch height in the partially curarized rat phrenic nerve hemidiaphragm preparation.
TLDR
It is shown that the addition of low concentrations of 5-HT to the indirectly stimulated partially curarized rat diaphragm preparation caused depression of twitch height.
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TLDR
The major finding was a markedly reduced initial rate of accumulation of serotonin 14 C into platelets from DMD patients, which may be of significance to the proposed vascular pathogenesis for DMD in raising the possibility of an alteration in biogenic amine deactivation at the microvascular level.
Calcium as mediator of isoproterenol-induced myocardial necrosis.
TLDR
It was concluded that ISO-induced myocardial necrosis is not mediated exclusively by flooding of heart muscle with plasma-derived calcium, although this is undoubtedly an important factor, and was further supported by experiments showing that propranolol, at doses which completely suppressed the increase in [Ca] due to ISO, did not completely prevent necrosis.
Increased Plasma Enzyme Concentrations in Rats with Functional Ischaemia of Muscle provide a Possible Model of Duchenne Muscular Dystrophy
TLDR
During the early and mid-stage histopathological lesions of Duchenne muscular dystrophy, serum enzyme levels of creatine phosphokinase (CPK), glutamic-oxaloacetic transaminase (GOT), glutamysial connective tissue between muscle fibres that are small, enlarged and sometimes with internal nuclei are markedly increased.
An experimental myopathy secondary to excessive acetylcholine release
TLDR
The results suggest that excessive acetylcholine can induce skeletal muscle necrosis even when the cholinesterase system is intact, and that the myopathy is not just the result of excessive depolarization and contraction but more likely is related to a disturbance in the trophic effect mediated by acetylCholine.
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