Skeletal muscle myofibrillar protein oxidation in heart failure and the protective effect of Carvedilol.

@article{Libera2005SkeletalMM,
  title={Skeletal muscle myofibrillar protein oxidation in heart failure and the protective effect of Carvedilol.},
  author={Luciano Dalla Libera and Barbara Ravara and Valerio Gobbo and Daniela Danieli Betto and Elena Germinario and Annalisa Angelini and Giorgio Vescovo},
  journal={Journal of molecular and cellular cardiology},
  year={2005},
  volume={38 5},
  pages={803-7}
}
Heart failure is characterized by limited exercise tolerance and by a skeletal muscle myopathy with atrophy and shift toward fast fibres. An inflammatory status with elevated pro-inflammatory cytokines and exaggerated free radicals production, can worsen muscle damage. In a well established model of heart failure, the monocrotaline treated rat, we show that CHF is accompanied by oxidation of the skeletal muscle actin, tropomyosin and myosin, which further depresses muscle function and exercise… CONTINUE READING

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