Skeletal muscle mitochondrial functions, mitochondrial DNA copy numbers, and gene transcript profiles in type 2 diabetic and nondiabetic subjects at equal levels of low or high insulin and euglycemia.

@article{Asmann2006SkeletalMM,
  title={Skeletal muscle mitochondrial functions, mitochondrial DNA copy numbers, and gene transcript profiles in type 2 diabetic and nondiabetic subjects at equal levels of low or high insulin and euglycemia.},
  author={Yan W. Asmann and Craig S. Stump and Kevin R Short and Jill M Coenen-Schimke and Zengkui Guo and Maureen L Bigelow and K. Sreekumaran Nair},
  journal={Diabetes},
  year={2006},
  volume={55 12},
  pages={3309-19}
}
We investigated whether previously reported muscle mitochondrial dysfunction and altered gene transcript levels in type 2 diabetes might be secondary to abnormal blood glucose and insulin levels rather than an intrinsic defect of type 2 diabetes. A total of 13 type 2 diabetic and 17 nondiabetic subjects were studied on two separate occasions while maintaining similar insulin and glucose levels in both groups by 7-h infusions of somatostatin, low- or high-dose insulin (0.25 and 1.5 mU/kg of fat… CONTINUE READING
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