Skeletal muscle mitochondrial energetics in obesity and type 2 diabetes mellitus: endocrine aspects.

@article{Aguer2012SkeletalMM,
  title={Skeletal muscle mitochondrial energetics in obesity and type 2 diabetes mellitus: endocrine aspects.},
  author={C{\'e}line Aguer and M H Harper},
  journal={Best practice & research. Clinical endocrinology & metabolism},
  year={2012},
  volume={26 6},
  pages={805-19}
}
During the development of type 2 diabetes mellitus, skeletal muscle is a major site of insulin resistance. The latter has been linked to mitochondrial dysfunction and impaired fatty acid oxidation. Some hormones like insulin, thyroid hormones and adipokines (e.g., leptin, adiponectin) have positive effects on muscle mitochondrial bioenergetics through their… CONTINUE READING