Skeletal muscle microvascular recruitment by physiological hyperinsulinemia precedes increases in total blood flow.

@article{Vincent2002SkeletalMM,
  title={Skeletal muscle microvascular recruitment by physiological hyperinsulinemia precedes increases in total blood flow.},
  author={Michelle A. Vincent and Dana K. Dawson and Andrew D H Clark and Jonathan R. Lindner and Stephen Rattigan and Michael S. G. Clark and Eugene J. Barrett},
  journal={Diabetes},
  year={2002},
  volume={51 1},
  pages={42-8}
}
Supraphysiological doses of insulin enhance total limb blood flow and recruit capillaries in skeletal muscle. Whether these processes change in response to physiological hyperinsulinemia is uncertain. To examine this, we infused either saline (n = 6) or insulin (euglycemic clamp, 3.0 mU x min(-1) x kg(-1), n = 9) into anesthetized rats for 120 min. Femoral artery flow was monitored continuously using a Doppler flow probe, and muscle microvascular recruitment was assessed by metabolism of… CONTINUE READING

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