Skeletal muscle lipid peroxidation and insulin resistance in humans.

  title={Skeletal muscle lipid peroxidation and insulin resistance in humans.},
  author={Katherine H. Ingram and Helliner S. Hill and Douglas R Moellering and Bradford G. Hill and Cristina Lara-Castro and Bradley R. Newcomer and L. Jerome Brandon and Christopher Paul Ingalls and Meera Penumetcha and Jeffrey C Rupp and W Timothy Garvey},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={97 7},
OBJECTIVE The relationships among skeletal muscle lipid peroxidation, intramyocellular lipid content (IMCL), and insulin sensitivity were evaluated in nine insulin-sensitive (IS), 13 insulin-resistant (IR), and 10 adults with type 2 diabetes (T2DM). DESIGN Insulin sensitivity was assessed by hyperinsulinemic-euglycemic clamp [glucose disposal rate (GDR)]. Lipid peroxidation was assessed by 4-hydroxynonenal (HNE)-protein adducts and general oxidative stress by protein carbonyl content. All… CONTINUE READING


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  • DM Huffman, DR Moellering, WE Grizzle, CR Stockard, MS Johnson, TR Nagy
  • 2008

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