Skeletal muscle is enriched in hematopoietic stem cells and not inflammatory cells in cachectic mice.

@article{Berardi2008SkeletalMI,
  title={Skeletal muscle is enriched in hematopoietic stem cells and not inflammatory cells in cachectic mice.},
  author={Emanuele Berardi and Paola Aulino and Ivana h Murfuni and Angelica Toschi and Fabrizio Padula and Bianca Maria Scicchitano and Dario h Coletti and Sergio Adamo},
  journal={Neurological research},
  year={2008},
  volume={30 2},
  pages={
          160-9
        }
}
OBJECTIVE Cachexia, a debilitating syndrome characterized by skeletal muscle wasting, is associated to many chronic diseases and diminishes the quality of life and survival of patients. Tumor-derived factors and proinflammatory cytokines, including TNF-alpha, IL-6 and IL-1 beta, mediate cachexia. In response to elevated cytokine levels, increased proteasome-mediated proteolysis and auto-phagocytosis result in muscle wasting. The histologic features of muscle cachexia are not fully elucidated… CONTINUE READING
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