Skeletal muscle interleukin-6 regulation in hyperthermia.

  title={Skeletal muscle interleukin-6 regulation in hyperthermia.},
  author={Steven S. Welc and Andrew R. Judge and Thomas L Clanton},
  journal={American journal of physiology. Cell physiology},
  volume={305 4},
We previously reported that IL-6 production is acutely elevated in skeletal muscles exposed to ≥41°C, but the regulatory pathways are poorly understood. The present study characterizes the heat-induced transcriptional control of IL-6 in C2C12 muscle fibers. Hyperthermia exposure (42°C for 1 h) induced transcription from an IL-6 promoter-luciferase reporter plasmid. Heat shock factor-1 (HSF-1), a principal mediator of the heat shock response, was then tested for its role in IL-6 regulation… CONTINUE READING