Skeletal muscle function and water permeability in aquaporin-4 deficient mice.

@article{Yang2000SkeletalMF,
  title={Skeletal muscle function and water permeability in aquaporin-4 deficient mice.},
  author={Baoxue Yang and Jean Marc Verbavatz and Yuanlin Song and L. Vetrivel and Geoffrey T. Manley and Wei-Yu Kao and Tonghui Ma and Alan S. Verkman},
  journal={American journal of physiology. Cell physiology},
  year={2000},
  volume={278 6},
  pages={C1108-15}
}
It has been proposed that aquaporin-4 (AQP4), a water channel expressed at the plasmalemma of skeletal muscle cells, is important in normal muscle physiology and in the pathophysiology of Duchenne's muscular dystrophy. To test this hypothesis, muscle water permeability and function were compared in wild-type and AQP4 knockout mice. Immunofluorescence and freeze-fracture electron microscopy showed AQP4 protein expression in plasmalemma of fast-twitch skeletal muscle fibers of wild-type mice… CONTINUE READING
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