Regulation of the myoblast fusion reaction for muscle development, regeneration, and adaptations.
- BiologyExperimental cell research
Fusion and beyond: Satellite cell contributions to loading‐induced skeletal muscle adaptation
- BiologyFASEB journal : official publication of the Federation of American Societies for Experimental Biology
This review highlights the current understanding of satellite cell behavior and contributions to adaptation outside of regeneration in adult muscle, as well as the roles of satellite cells beyond fusion and myonuclear accretion, which are gaining broader recognition.
Phosphatidylserine orchestrates Myomerger membrane insertions to drive myoblast fusion.
- BiologyProceedings of the National Academy of Sciences of the United States of America
Data reveal that Myomerger fusogenic activity is an exquisitely orchestrated event involving its two ectodomain helices, which are controlled by membrane lipid composition, providing an explanation as to how its membrane-stressing activity is spatially and temporally regulated during the final step of myoblast fusion.
Extraordinarily rapid proliferation of cultured muscle satellite cells from migratory birds
- BiologyBiology Letters
The results indicate that the rapid proliferation of satellite cells is not associated with total migration distance but may be related to flight bout duration and interact with lifespan.
Resistance Training Recommendations to Maximize Muscle Hypertrophy in an Athletic Population: Position Stand of the IUSCA
- EducationInternational Journal of Strength and Conditioning
Hypertrophy can be operationally defined as an increase in the axial cross-sectional area of a muscle fiber or whole muscle, and is due to increases in the size of pre-existing muscle fibers.…
Cross Talk proposal: Myonuclei are lost with ageing and atrophy
- BiologyThe Journal of physiology
Esther Dupont-Versteegden has investigated multiple mechanisms related to muscle atrophy and regrowth, such as the role of satellite cells, apoptosis and proteostasis, and has used interventions such as exercise and mechanotherapy to combat skeletal Muscle atrophy.
Gene editing of Duchenne muscular dystrophy using biomineralization-based spCas9 variant nanoparticles.
- Biology, EngineeringActa biomaterialia
SHOWING 1-10 OF 110 REFERENCES
Nuclear numbers in syncytial muscle fibers promote size but limit the development of larger myonuclear domains
- BiologyNature communications
It is proposed that as myonuclear numbers increase, the range of transcriptional return on a per nuclear basis in myofibers diminishes, which accounts for both the absolute reliance developing my ofibers have on nuclear accrual to establish size, and the limits of adaptability in adult skeletal muscle.
Single-nucleus RNA-seq identifies transcriptional heterogeneity in multinucleated skeletal myofibers
It is revealed that myonuclei within syncytial muscle fibers possess distinct transcriptional profiles that regulate muscle biology, and novel genes associated with rare specialized regions of the muscle cell are discovered.
Myonuclear domains in muscle adaptation and disease
- Biology, Environmental ScienceMuscle & nerve
Data demonstrate that modulation of myonuclear number or myonnuclear domain size is a mechanism contributing to the remodeling of adult skeletal muscle in response to alterations in the level of normal neuromuscular activity.
Myogenin is an essential regulator of adult myofibre growth and muscle stem cell homeostasis
- Biology, Environmental SciencebioRxiv
Beyond controlling myocyte fusion, Myog influences the MuSC:niche relationship, demonstrating a multi-level contribution to muscle homeostasis throughout life.
Myogenin promotes myocyte fusion to balance fibre number and size
- BiologyNature Communications
It is reported that loss of function of zebrafish myog prevents formation of almost all multinucleated muscle fibres and enhances Myomaker expression, muscle cell fusion and myotome size, yet decreases fast muscle fibre number.
Satellite cell depletion prevents fiber hypertrophy in skeletal muscle
It is discussed that there is currently no model in which functional, sustainable hypertrophy has been unequivocally demonstrated in the absence of satellite cells; an exception is re-growth, which can occur using previously recruited myonuclei without addition of new myon nuclei.
Myonuclear content regulates cell size with similar scaling properties in mice and humans
- BiologyNature communications
Scaling exponents are remarkably similar across species, developmental stages and experimental conditions, suggesting an underlying scaling law where DNA-content functions as a limiter of muscle cell size.
Requirement of myomaker-mediated stem cell fusion for skeletal muscle hypertrophy
An essential contribution of myomaker-mediated stem cell fusion during physiological adult muscleHypertrophy is revealed, indicating a protective role for normal stem cell activity in reducing myofiber strain associated with hypertrophy.
Muscle hypertrophy driven by myostatin blockade does not require stem/precursor-cell activity
- BiologyProceedings of the National Academy of Sciences
Findings contradict the accepted model of myostatin-based control of size of postnatal muscle and reorient fundamental investigations away from the mechanisms that control satellite cell proliferation and toward those that increase myonuclear domain, by modulating synthesis and turnover of structural muscle fiber proteins.