Skeletal muscle fatigue: cellular mechanisms.

@article{Allen2008SkeletalMF,
  title={Skeletal muscle fatigue: cellular mechanisms.},
  author={David G. Allen and G. D. Lamb and H{\aa}kan Westerblad},
  journal={Physiological reviews},
  year={2008},
  volume={88 1},
  pages={287-332}
}
Repeated, intense use of muscles leads to a decline in performance known as muscle fatigue. Many muscle properties change during fatigue including the action potential, extracellular and intracellular ions, and many intracellular metabolites. A range of mechanisms have been identified that contribute to the decline of performance. The traditional explanation, accumulation of intracellular lactate and hydrogen ions causing impaired function of the contractile proteins, is probably of limited… CONTINUE READING
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