Skeletal muscle disuse induces fibre type-dependent enhancement of Na(+) channel expression.

@article{Desaphy2001SkeletalMD,
  title={Skeletal muscle disuse induces fibre type-dependent enhancement of Na(+) channel expression.},
  author={Jean-François Desaphy and Sabata Pierno and Claude L{\'e}oty and Alfred L. George and Annamaria De Luca and Diana Conte Camerino},
  journal={Brain : a journal of neurology},
  year={2001},
  volume={124 Pt 6},
  pages={
          1100-13
        }
}
Slow-twitch and fast-twitch muscle fibres have specific contractile properties to respond to specific needs. Since sodium current density is higher in fast-twitch than in slow-twitch fibres, sodium channels contribute to the phenotypic feature of myofibres. Phenotype determination is not irreversible: after periods of rat hindlimb unloading (HU), a model of hypogravity, a slow-to-fast transition occurs together with atrophy in the antigravity slow-twitch soleus muscle. Using cell-attached patch… CONTINUE READING

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