Skeletal muscle cells expressing VEGF induce capillary formation and reduce cardiac injury in rats.

@article{Becker2006SkeletalMC,
  title={Skeletal muscle cells expressing VEGF induce capillary formation and reduce cardiac injury in rats.},
  author={Cl{\'a}udia Becker and Silvia Lacchini and Alysson Renato Muotri and Gustavo Jos{\'e} Justo da Silva and Jussara Bianchi Castelli and Paula Frizera Vassallo and Carlos Frederico Martins Menck and Jos{\'e} Eduardo Krieger},
  journal={International journal of cardiology},
  year={2006},
  volume={113 3},
  pages={348-54}
}
BACKGROUND We tested a preemptive combined cell/gene therapy strategy of skeletal myoblasts transfected with Ad(5)RSVVEGF-165 in an ischemia/reperfusion rat model to increase collateral blood flow to nonischemic heart tissue. METHODS Lewis rats were injected with placebo (Control), 10(6) skeletal myoblasts (SkM), or 10(6) skeletal myoblasts transfected with Ad(5)RSVVEGF-165 (SkM(+)) into the left ventricle 1week before ischemia. Left ventricle end-diastolic pressure, scar area, and capillary… CONTINUE READING

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