Skeletal muscle autophagy and apoptosis during aging: effects of calorie restriction and life-long exercise.

@article{Wohlgemuth2010SkeletalMA,
  title={Skeletal muscle autophagy and apoptosis during aging: effects of calorie restriction and life-long exercise.},
  author={Stephanie Eva Wohlgemuth and Arnold Young Seo and Emanuele Marzetti and Hazel Anne Lees and Christiaan Leeuwenburgh},
  journal={Experimental gerontology},
  year={2010},
  volume={45 2},
  pages={138-48}
}
Sarcopenia, loss of muscle mass and function, is a common feature of aging. Oxidative damage and apoptosis are likely underlying factors. Autophagy, a process for the degradation of cellular constituents, may be a mechanism to combat cell damage and death. We investigated the effect of age on autophagy and apoptosis in plantaris muscle of male Fischer 344 rats that were either fed ad libitum, or mild, life-long calorie restricted (CR) alone or combined with life-long voluntary exercise… CONTINUE READING
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