Skeletal muscle apoptosis, sarcopenia and frailty at old age

@article{Marzetti2006SkeletalMA,
  title={Skeletal muscle apoptosis, sarcopenia and frailty at old age},
  author={Emanuele Marzetti and Christiaan Leeuwenburgh},
  journal={Experimental Gerontology},
  year={2006},
  volume={41},
  pages={1234-1238}
}

Multiple Pathways to the Same End: Mechanisms of Myonuclear Apoptosis in Sarcopenia of Aging

Further research is required to better define the involvement of myocyte apoptosis in the pathogenesis of muscle loss at advanced age, which will likely help in the design of more effective therapeutic strategies to preserve muscle mass into old age, thus fostering independence of the elderly population and reducing the socioeconomic burden associated with sarcopenia.

One size may not fit all: anti-aging therapies and sarcopenia

Sarcopenia may represent a unique phenotypic feature of aging that requires specific and individually tailored therapeutic strategies to halt or reverse the progression of sarcopenia.

Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy

Current knowledge on the mechanisms whereby mitochondrial dysfunction intervenes in the pathogenesis of sarcopenia and disuse atrophy are summarized, and the prospect of targeting specific processes to treat these conditions is highlighted.

Sarcopenia of aging: Underlying cellular mechanisms and protection by calorie restriction

Preliminary evidence indicates that moderate CR may promote muscle mitochondrial biogenesis in middle‐aged human subjects, and further research is warranted to investigate whether CR may represent a safe and efficient strategy to delay the onset and mitigate the progression of sarcopenia in older adults.

PGC-1α and Myokines in the Aging Muscle – A Mini-Review

Current discoveries about the peroxisome proliferator-activated receptor γ coactivator-1 α (PGC-1α), a key exercise factor in muscle, and myokines, factors produced and secreted by active muscle fibers, expand the view of the pathological changes and the therapeutic options for sarcopenia.

Potential mechanisms underlying the role of chronic inflammation in age-related muscle wasting

An evidence-based review serves to examine sarcopenia from a mechanistic perspective with emphasis on chronic inflammation, as the co-existence of such adverse alterations in body composition may exacerbate systemic inflammation and muscle wasting in the elderly.

Sarcopenia – Molecular mechanisms and open questions

Models of accelerated sarcopenia: Critical pieces for solving the puzzle of age-related muscle atrophy

...

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