Skeletal muscle and the control of ventilation on exercise: evidence for metabolic receptors.

@article{Clark1995SkeletalMA,
  title={Skeletal muscle and the control of ventilation on exercise: evidence for metabolic receptors.},
  author={Andy Clark and Massimo Francesco Piepoli and Andrew J S Coats},
  journal={European journal of clinical investigation},
  year={1995},
  volume={25 5},
  pages={299-305}
}
Patients with chronic heart failure have an increased ventilatory response to exercise, and have metabolically abnormal skeletal muscle. It has been proposed that a neural signal to ventilation arising from exercising muscle may be heightened in chronic heart failure. Our objective was to detect evidence for such a signal in normal subjects by studying ventilatory behaviour during exercise with muscles in different metabolic states. Fifteen normal subjects undertook treadmill exercise both with… CONTINUE READING

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