Skeletal metamorphosis in fibrodysplasia ossificans progressiva (FOP)

@article{Kaplan2008SkeletalMI,
  title={Skeletal metamorphosis in fibrodysplasia ossificans progressiva (FOP)},
  author={Frederick S. Kaplan and Qi Shen and Vitali Y. Lounev and Petra Seemann and Jay C. Groppe and Takenobu Katagiri and Robert J. Pignolo and Eileen M Shore},
  journal={Journal of Bone and Mineral Metabolism},
  year={2008},
  volume={26},
  pages={521-530}
}
Metamorphosis, the transformation of one normal tissue or organ system into another, is a biological process rarely studied in higher vertebrates or mammals, but exemplified pathologically by the extremely disabling autosomal dominant disorder fibrodysplasia ossificans progressiva (FOP). The recurrent single nucleotide missense mutation in the gene encoding activin receptor IA/activin-like kinase-2 (ACVR1/ALK2), a bone morphogenetic protein type I receptor that causes skeletal metamorphosis in… CONTINUE READING

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Trace element and cytokine concentrations in patients with Fibrodysplasia Ossificans Progressiva (FOP): A case control study.

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