Skeletal malformations induced by mitomycin C in chick embryos.

One hundred and eighty chick embryos were studied for the presence of skeletal malformations after administration of mitomycin C at 72, 96 and 120 hours of incubation. Axial skeleton defects included those of ribs, vertebrae, beak and crania. Appendicular skeletal defects were mainly confined to the lower limbs e.g. absence of phalanges, bent and shortened… (More)