Skeletal localization of samarium-153 chelates: potential therapeutic bone agents.

  title={Skeletal localization of samarium-153 chelates: potential therapeutic bone agents.},
  author={William F. Goeckeler and Bryan Edwards and Wynn A. Volkert and Richard A. Holmes and Joel Varghese Simon and Debbie A Wilson},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  volume={28 4},
A series of stable complexes of 153Sm has been produced using multidentate acetate and phosphonate ligands. Biodistribution studies in unanesthetized rats showed varying degrees of bone and soft-tissue uptake for these complexes. Of the complexes studied, [153Sm] ethylenediaminetetramethylenephosphonate (EDTMP) showed the best combination of high bone uptake, low nonosseous uptake, and rapid blood clearance which warranted its further investigation in rabbits. Rabbit studies confirmed the… CONTINUE READING


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