Skeletal and cardiac myopathy in HIV-1 transgenic rats.

  title={Skeletal and cardiac myopathy in HIV-1 transgenic rats.},
  author={Anne M. Pruznak and Ly Q Hong-Brown and Rachel Lantry and Pengxiang She and R. Frost and Thomas C. Vary and Charles H Lang},
  journal={American journal of physiology. Endocrinology and metabolism},
  volume={295 4},
The mechanism by which human immunodeficiency virus (HIV)-1 infection in humans leads to the erosion of lean body mass is poorly defined. Therefore, the purpose of the present study was to determine whether transgenic (Tg) rats that constitutively overexpress HIV-1 viral proteins exhibit muscle wasting and to elucidate putative mechanisms. Over 7 mo, Tg rats gained less body weight than pair-fed controls exclusively as a result of a proportional reduction in lean, not fat, mass. Fast- and slow… CONTINUE READING