Skeletal aging and the adipocyte program: New insights from an "old" molecule.

  title={Skeletal aging and the adipocyte program: New insights from an "old" molecule.},
  author={Beata Lecka-Czernik and Clifford J. Rosen and Masanobu Kawai},
  journal={Cell cycle},
  volume={9 18},
Aging is associated with profound changes in bone mass and body composition. Emerging evidence supports the hypothesis that alterations in mesenchymal stromal cell fate are a critical etiologic factor. In addition, time-keeping at the cellular level is affected as aging progresses, particularly in the adipocyte. In this Extra View we discuss the interactive role of three molecules, PPARγ, nocturnin and IGF-I in regulating stem cell fate in the marrow and the potential implications of this… CONTINUE READING
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