Skeletal Muscle-specific PGC-1α Overexpression Suppresses Atherosclerosis in Apolipoprotein E-Knockout Mice

@inproceedings{Shimba2019SkeletalMP,
  title={Skeletal Muscle-specific PGC-1α Overexpression Suppresses Atherosclerosis in Apolipoprotein E-Knockout Mice},
  author={Yuki Shimba and Hanako Togawa and Nanami Senoo and Masahiko Ikeda and Noriyuki Miyoshi and Akihito Morita and Shinji Miura},
  booktitle={Scientific Reports},
  year={2019}
}
Endurance exercise training prevents atherosclerosis. Peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) increases myokine secretion from the skeletal muscle, and these myokines have been shown to affect the function of multiple organs. Since endurance exercise training increases PGC-1α expression in skeletal muscles, we investigated whether skeletal muscle-specific PGC-1α overexpression suppresses atherosclerosis. Apolipoprotein E-knockout (ApoE-KO)/PGC-1α mice, which… CONTINUE READING

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