Skeletal Muscle, but not Cardiovascular Function, Is Altered in a Mouse Model of Autosomal Recessive Hypophosphatemic Rickets

Abstract

Autosomal recessive hypophosphatemic rickets (ARHR) is a heritable disorder characterized by hypophosphatemia, osteomalacia, and poor bone development. ARHR results from inactivating mutations in the DMP1 gene with the human phenotype being recapitulated in the Dmp1 null mouse model which displays elevated plasma fibroblast growth factor 23. While the bone… (More)
DOI: 10.3389/fphys.2016.00173

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Cite this paper

@article{Wacker2016SkeletalMB, title={Skeletal Muscle, but not Cardiovascular Function, Is Altered in a Mouse Model of Autosomal Recessive Hypophosphatemic Rickets}, author={Michael J. Wacker and Chad D. Touchberry and Neerupma Silswal and Leticia S. Brotto and Chris J. Elmore and Lynda F. Bonewald and Jon J. Andresen and Marco Brotto}, journal={Frontiers in physiology}, year={2016}, volume={7}, pages={173} }